Part I: Scientific progress & Basic Proteases
Whether you are a ground, instant, or caffeine-free coffee lover, recent science has brought good news. Ingredients in coffee, such as caffeine, chlorogenic acid, and isochlorogenic acid, can help us reduce infection with Sars-Cov-2 risks [1]. Drinking coffee helps block the entry of Sars-Cov-2 into host cells, and this blocking seal includes most variants such as Alpha, Delta and Omicron. This “coffee barrier”（Coffee Kekkai / 咖啡結界） is completed by the interaction of coffee components with different proteases in host cells, thereby achieving mechanisms such as inhibiting the binding and reducing the activity of cells and Sars-Cov-2 . ...
Part II : Coffee’s Collaborative Protection and Unknown Ingredients
Reference:
[1]News-Medical.Net: Coffee and COVID: Study finds coffee inhibits SARS-CoV-2, offers new dietary defense strategy, 2023-11-16, https://www.news-medical.net/news/20231116/Coffee- and-COVID-Study-finds-coffee-inhibits-SARS-CoV-2-offers-new-dietary-defense-strategy.aspx .
[2] Vu, T. H. T., Rydland, K. J., Achenbach, C. J., Van Horn, L., & Cornelis, M. C. (2021). Dietary behaviors and incident COVID-19 in the UK Biobank. Nutrients, 13(6), 2114.
[3] Wu, C. S., Li, Y. C., Peng, S. L., Chen, C. Y., Chen, H. F., Hsueh, P. R., ... & Hung, M. C. (2023). Coffee as a dietary strategy to prevent SARS-CoV-2 infection. Cell & Bioscience, 13(1), 210.
[4] Vargas-Alarcón, G., Posadas-Sánchez, R., & Ramírez-Bello, J. (2020). Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies. Life Sciences, 260, 118313.
Jackson, CB, Farzan, M., Chen, B., & Choe, H. (2022). Mechanisms of SARS-CoV-2 entry into cells . Nature reviews Molecular cell biology , 23(1), 3-20.
[5] U.S. National Library of Medicine ACE2 : https://www.ncbi.nlm.nih.gov/gene/59272
Turner, AJ, & Nalivaeva, NN (2022). Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation . Peptides , 151, 170766.
[6] U.S. National Library of Medicine TMPRSS2 : https://www.ncbi.nlm.nih.gov/gene/7113
Jackson, C. B., Farzan, M., Chen, B., & Choe, H. (2022). Mechanisms of SARS-CoV-2 entry into cells. Nature reviews Molecular cell biology, 23(1), 3-20.
Epstein, R. J. (2021). The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor. Tumor Biology, 43(1), 159-176.
[7] 美國國家醫學圖書館CTSL : https://www.ncbi.nlm.nih.gov/gene/1514
Weiss-Sadan, T., Itzhak, G., Kaschani, F., Yu, Z., Mahameed, M., Anaki, A., ... & Blum, G. (2019). Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation [S]. Molecular & Cellular Proteomics, 18(7), 1330-1344.
Zhao, Miao-Miao, et al. "Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies." Cell Discovery 8.1 (2022): 53.
[8] Romero-Martinez, B. S., Montano, L. M., Solis-Chagoyan, H., Sommer, B., Ramirez-Salinas, G. L., Perez-Figueroa, G. E., & Flores-Soto, E. (2021). Possible beneficial actions of caffeine in SARS-CoV-2. International Journal of Molecular Sciences, 22(11), 5460.
[9] Sci.News. Coffee Compound Reduces Binding of SARS-CoV-2 Virus to Its Human Target, Study Shows, Nov.15, 2022. https://www.sci.news/medicine/coffee-compound-sars-cov-2-virus-11391.html
[10] Ahvanooei, M. R., Norouzian, M. A., & Vahmani, P. (2021). Beneficial effects of vitamins, minerals, and bioactive peptides on strengthening the immune system against COVID-19 and the role of cow’s milk in the supply of these nutrients. Biological trace element research, 1-14.
[11] Sumimura Yoshimori is the protagonist of the well-known manga / anime " Boundary Master " . He likes to drink coffee and milk on weekdays .